“Paradoxical Kinesis” is not a Hallmark of Parkinson's disease but a general property of the motor system
Identifieur interne : 000352 ( France/Analysis ); précédent : 000351; suivant : 000353“Paradoxical Kinesis” is not a Hallmark of Parkinson's disease but a general property of the motor system
Auteurs : Bénédicte Ballanger [France] ; Stéphane Thobois [France] ; Pierre Baraduc [France] ; Robert S. Turner [États-Unis] ; Emmanuel Broussolle [France] ; Michel Desmurget [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-09.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Arousal (physiology), Cues, Dominance, Cerebral (physiology), Female, Humans, Hypokinesia (diagnosis), Hypokinesia (physiopathology), Male, Middle Aged, Motion Perception (physiology), Motivation, Motor Activity (physiology), Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson disease, Psychomotor Performance (physiology), Reaction Time (physiology), Reaction time, Stress, movement time, reaching, reaction time, self‐initiated movement, stress.
- MESH :
- diagnosis : Hypokinesia, Parkinson Disease.
- physiology : Arousal, Dominance, Cerebral, Motion Perception, Motor Activity, Psychomotor Performance, Reaction Time.
- physiopathology : Hypokinesia, Parkinson Disease.
- Aged, Cues, Female, Humans, Male, Middle Aged, Motivation.
Abstract
Although slowness of movement is a typical feature of Parkinson's disease (PD), it has been suggested that severely disabled patients remained able to produce normal motor responses in the context of urgent or externally driven situations. To investigate this phenomenon (often designated “paradoxical kinesis”), we required PD patients and healthy subjects to press a large switch under three main conditions: Self Generated, produce the fastest possible movement; External Cue, same as Self Generated but in response to an acoustic cue; Urgent External Cue, same as External Cue with the switch controlling an electromagnet that prevented a ball falling at the bottom of a tilted ramp. Task difficulty was equalized for the two experimental groups. Results showed that external cues and urgent conditions decreased movement duration (Urgent External Cue < External Cue < Self Generated) and reaction time (Urgent External Cue < External Cue). The amount of reduction was identical in PD patients and healthy subjects. These observations show that paradoxical kineses are not a hallmark of PD or a byproduct of basal ganglia dysfunctions, but a general property of the motor system. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20987
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-09">2006-09</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1490">1490</biblScope><biblScope unit="page" to="1495">1495</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">941C0C7FDC1F1E047489A8DB7ECB7EBFC8770EE3</idno><idno type="DOI">10.1002/mds.20987</idno><idno type="ArticleID">MDS20987</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arousal (physiology)</term><term>Cues</term><term>Dominance, Cerebral (physiology)</term><term>Female</term><term>Humans</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Motion Perception (physiology)</term><term>Motivation</term><term>Motor Activity (physiology)</term><term>Nervous system diseases</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (physiology)</term><term>Reaction time</term><term>Stress</term><term>movement time</term><term>reaching</term><term>reaction time</term><term>self‐initiated movement</term><term>stress</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Arousal</term><term>Dominance, Cerebral</term><term>Motion Perception</term><term>Motor Activity</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cues</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motivation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Stress</term><term>Système nerveux pathologie</term><term>Temps réaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although slowness of movement is a typical feature of Parkinson's disease (PD), it has been suggested that severely disabled patients remained able to produce normal motor responses in the context of urgent or externally driven situations. To investigate this phenomenon (often designated “paradoxical kinesis”), we required PD patients and healthy subjects to press a large switch under three main conditions: Self Generated, produce the fastest possible movement; External Cue, same as Self Generated but in response to an acoustic cue; Urgent External Cue, same as External Cue with the switch controlling an electromagnet that prevented a ball falling at the bottom of a tilted ramp. Task difficulty was equalized for the two experimental groups. Results showed that external cues and urgent conditions decreased movement duration (Urgent External Cue < External Cue < Self Generated) and reaction time (Urgent External Cue < External Cue). The amount of reduction was identical in PD patients and healthy subjects. These observations show that paradoxical kineses are not a hallmark of PD or a byproduct of basal ganglia dysfunctions, but a general property of the motor system. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Bénédicte" last="Ballanger">Bénédicte Ballanger</name></noRegion><name sortKey="Baraduc, Pierre" sort="Baraduc, Pierre" uniqKey="Baraduc P" first="Pierre" last="Baraduc">Pierre Baraduc</name><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Desmurget, Michel" sort="Desmurget, Michel" uniqKey="Desmurget M" first="Michel" last="Desmurget">Michel Desmurget</name><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Turner, Robert S" sort="Turner, Robert S" uniqKey="Turner R" first="Robert S." last="Turner">Robert S. 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